Spontaneous Diseases in Commonly Used Mouse Strains
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منابع مشابه
A Wistar rat strain prone to spontaneous liver tumor development: implications for carcinogenic risk assessment.
The European Union legislation considers nongenotoxic substances that only cause liver tumors in certain sensitive strains of mice as raising no concern for man. The EU legislation, however, also clearly stipulates that cases where the only available tumor data are the occurrence of neoplasms at sites and in strains where they are well known to occur spontaneously with a high incidence are rele...
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OBJECTIVE To characterize differences in whole-body glucose metabolism between commonly used inbred mouse strains. RESEARCH DESIGN AND METHODS Hyperinsulinemic-euglycemic (approximately 8.5 mmol/l) and -hypoglycemic (approximately 3.0 mmol/l) clamps were done in catheterized, 5-h-fasted mice to assess insulin action and hypoglycemic counter-regulatory responsiveness. Hyperglycemic clamps (app...
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Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder in which complex genetic factors play an important role. Several strains of gene-targeted mice have been reported to develop SLE, implicating the null genes in the causation of disease. However, hybrid strains between 129 and C57BL/6 mice, widely used in the generation of gene-targeted mice, develop spontaneous autoimmunity...
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Background & Objective: Non-traumatic pneumothorax is mostly caused by the disruption of small and large bulla in lungs. Approximately 80% of the patients with spontaneous pneumothorax are thin, tall young men without the history of respiratory disorders. In patients over 40 years old there is a noticeable lung disease, mostly emphysema in smokers. Catamential pneumothorax is a rare phenom...
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